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Non-Destructive Fingerprinting of Compounds


Drug Formulations & Precursors:

Simple, Low-Cost
Compact XRD-XRF
Minimal Sample Prep

All drug formulations have a unique fingerprint of both active and inactive ingredients that identifies the efficacy and brand of each drug. Incorrect formulations containing foreign or substitute ingredients can jeopardize a patient's well-being. Additionally, when incorrect or counterfeit formulations are distributed under a brand name, the reputation of the manufacturer is at risk. Drug manufacturers must protect their business interests by ensuring that the correct formulations of their products are being distributed. This will ensure that patients are receiving the correct formulation, that their branding isn't compromised by counterfeiters, and that they have documented fingerprint records of all their drug and formulation steps. A non-destructive fingerprinting method for drug formulations is essential for pharmaceutical manufacturers. It offers factual support for patent and other legal records as well as retention of the original powder material if needed.

BTX testing a sample

A drug formulation, at any stage, can be quickly scanned for its fingerprint by measuring its crystalline structure. Pharmaceutical fingerprinting is commonly done using XRD. The BTX combines both XRD fingerprinting and XRF elemental ID to perform rapid, thorough identification with its unique sample handling system that leaves the formulation intact for further or future testing.

Operation of the BTX is as EASY as 1, 2, 3

BTX sample chamber

1. Place powdered drug into holder

2. Insert sample holder into BTX

3. Press "Start" to record fingerprint

Popular Male Enhancement Drug Formulation Fingerprints from Two Different Distribution Channels

comparison data of drug components
The red fingerprint is the manufacturer's correct formulation of the male enhancement drug. The blue fingerprint is marketed as the same male enhancement drug and distributed on the internet. It is actually gypsum and contains no active ingredient for the male enhancement drug at all.

Phase Analysis data
Available phase identification pattern matching software provides a complete analysis using either publicly available diffraction pattern databases or common commercially available databases, such as PDF2/PDF4.

Basic Specifications
Weight: 14.5 kg with 4 batteries
Size: 48.5 x 39.2 x 19.2 cm / 19.1 x 15.4 x 7.6 in
XRD Resolution: 0.25° 2T FWHM
XRD Range: 5-55° 2T
Detector Type: 1024 x 256 pixels; 2D Peltier-cooled CCD
XRF Energy Resolution: 230 eV (at 5.9 keV)
XRF Energy Range: 3-25 keV
Sample Grain Size: <150µ crushed minerals (100 mesh screen, 150 um)
Sample Quantity: >15mg; smaller sample holder available on special order
X-Ray Target Material: Cobalt (others available on request)
X-Ray Tube Voltage: 30kV
X-Ray Tube Wattage: 10W
Field Autonomy: ~4 hours (can be expanded by hot swapping batteries)
Power Consumption: 85-90W during analysis
Data Storage: 40Gb; Ruggedized internal hard drive
Wireless Connectivity: 802.11 b/g for remote control from web browser
Operating Temperature: -20° to 35°C
Enclosure: IP67, MIL C-4150J ; rugged case
Specifications subject to change without notice.
Olympus IMS
应用所使用的产品

TERRA可移动XRD系统是一款高性能、全封闭、电池操作、封闭声束型手持式XRD,可提供对材料主要成分、次要成分或微量成分进行辨别的全面概括总结,可以通过一次快速XRF扫查对钙和铀元素在被测产品中所占比例进行检测。这种极为简单的独特的采样准备技术以及样件箱体使得快速的现场分析成为可能。
BTX工作台式XRD系统是一款快速、低成本、小脚印、可放于工作台上的XRD,可提供对材料主要成分、次要成分或微量成分进行辨别的全面概括总结,可以通过一次快速XRF扫查对钙和铀元素在被测产品中所占比例进行检测。与耗资极高的大型实验室设备相比,这种极为简单的独特的采样准备技术及样件箱体使得在工作台上的快速的分析成为可能。
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