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Non-Destructive Fingerprinting of Compounds


Drug Formulations & Precursors:

Simple, Low-Cost
Compact XRD-XRF
Minimal Sample Prep

All drug formulations have a unique fingerprint of both active and inactive ingredients that identifies the efficacy and brand of each drug. Incorrect formulations containing foreign or substitute ingredients can jeopardize a patient's well-being. Additionally, when incorrect or counterfeit formulations are distributed under a brand name, the reputation of the manufacturer is at risk. Drug manufacturers must protect their business interests by ensuring that the correct formulations of their products are being distributed. This will ensure that patients are receiving the correct formulation, that their branding isn't compromised by counterfeiters, and that they have documented fingerprint records of all their drug and formulation steps. A non-destructive fingerprinting method for drug formulations is essential for pharmaceutical manufacturers. It offers factual support for patent and other legal records as well as retention of the original powder material if needed.

BTX testing a sample

A drug formulation, at any stage, can be quickly scanned for its fingerprint by measuring its crystalline structure. Pharmaceutical fingerprinting is commonly done using XRD. The BTX combines both XRD fingerprinting and XRF elemental ID to perform rapid, thorough identification with its unique sample handling system that leaves the formulation intact for further or future testing.

Operation of the BTX is as EASY as 1, 2, 3

BTX sample chamber

1. Place powdered drug into holder

2. Insert sample holder into BTX

3. Press "Start" to record fingerprint

Popular Male Enhancement Drug Formulation Fingerprints from Two Different Distribution Channels

comparison data of drug components
The red fingerprint is the manufacturer's correct formulation of the male enhancement drug. The blue fingerprint is marketed as the same male enhancement drug and distributed on the internet. It is actually gypsum and contains no active ingredient for the male enhancement drug at all.

Phase Analysis data
Available phase identification pattern matching software provides a complete analysis using either publicly available diffraction pattern databases or common commercially available databases, such as PDF2/PDF4.

Basic Specifications
Weight: 14.5 kg with 4 batteries
Size: 48.5 x 39.2 x 19.2 cm / 19.1 x 15.4 x 7.6 in
XRD Resolution: 0.25° 2T FWHM
XRD Range: 5-55° 2T
Detector Type: 1024 x 256 pixels; 2D Peltier-cooled CCD
XRF Energy Resolution: 230 eV (at 5.9 keV)
XRF Energy Range: 3-25 keV
Sample Grain Size: <150µ crushed minerals (100 mesh screen, 150 um)
Sample Quantity: >15mg; smaller sample holder available on special order
X-Ray Target Material: Cobalt (others available on request)
X-Ray Tube Voltage: 30kV
X-Ray Tube Wattage: 10W
Field Autonomy: ~4 hours (can be expanded by hot swapping batteries)
Power Consumption: 85-90W during analysis
Data Storage: 40Gb; Ruggedized internal hard drive
Wireless Connectivity: 802.11 b/g for remote control from web browser
Operating Temperature: -20° to 35°C
Enclosure: IP67, MIL C-4150J ; rugged case
Specifications subject to change without notice.
Olympus IMS

Products Used for This Application
The TERRA™ II XRD analyzer provides portable quantitative mineralogy. Featuring a battery life up to six hours and a rugged, weatherproof case, the system is built for fast in-field analysis of major and minor components.
The BTX™ III XRD analyzer offers reliable quantitative mineralogy of major and minor components in a compact, benchtop design. Powerful software is paired with an improved X-ray detector for increased speed and sensitivity.
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